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Body weight is influenced by multiple factors including genetics, diet, neurotransmitter function, physical activity, and stress. When excess weight is introduced, particularly in the midsection, complex interactions occur among these elements that can affect multiple aspects of health. Elevated adrenal stress hormones are also associated with being overweight. These hormones interact with brain neurotransmitters, negatively impacting mood and appetite control, which can often derail efforts toward healthy weight management.